Publications

Publications

34. Pulling with the Pentafluorosulfanyl (SF5) Acceptor in Push-Pull Dyes

Gautam, P.; Yu, C. P.; Zhang, G.; Hillier, V. E.; Chan, J. M. W.*

J. Org. Chem. 2017, Accepted, DOI: 10.1021/acs.joc.7b01972 PDF

33. Reversibly Thermochromic Bismuth-Organic Materials with Tunable Optical Gaps

Zhang, G.; Chan, J. M. W.*

J. Mater. Chem. C 2017, 5, 10007-10015. PDF
32. Highly Potent Antimicrobial Polyionenes with Rapid Killing Kinetics, Skin Biocompatibility and in vivo Bactericidal Activity

Liu, S.; Ono, R. J.; Wu, H.; Teo, J. Y.; Liang, Z. C.; Xu, K.; Zhang, M.; Zhong, G.; Tan, J. P. K.; Ng, M.; Yang, C.; Chan, J. M. W.; Ji, Z.; Bao, C.; Kumar, K.; Gao, S.; Lee, A.; Fevre, M.; Dong, H.; Ying, J. Y.; Li, L.; Fan, W.; Hedrick, J. L.; Yang, Y. Y.

Biomaterials 2017, 127, 36-48. PDF
31. Self-Assembled, Biodegradable Magnetic Resonance Imaging Agents: Organic Radical-Functionalized Diblock Copolymers

Chan, J. M. W.; Wojtecki, R. J.; Sardon, H.; Lee, A. L. Z.; Smith, C. E.; Shkumatov, A.; Gao, S.; Kong, H.; Yang, Y. Y.; Hedrick, J. L.

ACS Macro Lett. 2017, 6, 176-180. PDF
30. Sultam-based Hetero[5]helicene: Synthesis, Structure, and Crystallization-Induced Emission Enhancement

Virk, T. S.; Ilawe, N. V.; Zhang, G.; Yu, C. P.; Wong, B. M.; Chan, J. M. W.*

ACS Omega 2016, 1, 1336-1342. PDF
blue crystals
29. Organocatalytic Anticancer Drug Loading of Degradable Polymeric Mixed Micelles via a Biomimetic Mechanism

Chan, J. M. W.; Tan, J. P. K.; Engler, A. C.; Ke, X.; Gao, S.; Yang, C.; Sardon, H.; Yang, Y. Y.; Hedrick, J. L.

Macromolecules 2016, 49, 2013-2021. PDF.

Among Top 20 most read articles of Mar & Apr 2016.
Polycarbonates, polymer synthesis, graft polymers
28. Design and Synthesis of Biodegradable Grafted Cationic Polycarbonates as Broad Spectrum Antimicrobial Agents

Ong, Z. Y.; Coady, D. J.; Tan, J. P. K.; Li, Y.; Chan, J. M. W.; Hedrick, J. L.; Yang, Y. Y.

J. Polym. Sci., Part A: Polym. Chem. 2016, 54, 1029-1035. PDF.

Spotlight Article.
Polycarbonates, polymer synthesis, graft polymers
27. Thermoresponsive Random Poly(ether urethanes) with Tailorable LCSTs for Anticancer Drug Delivery

Sardon, H.; Tan, J. P. K.; Chan, J. M. W.; Mantione, D.; Mecerreyes, D.; Hedrick, J. L.; Yang, Y. Y.

Macromol. Rapid Commun. 2015, 36, 1761-1767. PDF
Polyurethanes, polymer synthesis, LCST
26. Broad-Spectrum Antimicrobial Polycarbonate Hydrogels with Fast Degradability

Pascual, A.; Tan, J. P. K.; Chan, J. M. W.; Coady, D. J.; Mecerreyes, D.; Hedrick, J. L.; Yang, Y. Y.; Sardon, H.

Biomacromolecules 2015, 16, 1169-1178. PDF
Polycarbonate, hydrogel
25. Hydrophilic Polycarbonates: Promising Degradable Alternatives to Poly(ethylene glycol)-based Stealth Materials

Engler, A. C.; Ke, X.; Gao, S.; Chan, J. M. W.; Coady, D. J.; Ono, R. J.; Lubbers, R.; Nelson, A.; Yang, Y. Y.; Hedrick, J. L.

Macromolecules 2015, 48, 1673-1678. PDF
Polycarbonate, stealth polymer, PEG alternative
24. Polyurethane-coated Silica Particles with Broad-Spectrum Antibacterial Properties

Xu, Q.; Sardon, H.; Chan, J. M. W.; Hedrick, J. L.; Yang, Y. Y.

Polym. Chem. 2015, 6, 2011-2022. PDF
Polyurethane nanoparticles
23. Organocatalytic Ring-Opening Polymerization of Trimethylene Carbonate to Yield a Biodegradable Polycarbonate

Chan, J. M. W.*; Zhang, X.; Sardon, H.; Engler, A. C.; Fox, C. H.; Frank, C. W.; Waymouth, R. M.; Hedrick, J. L.

J. Chem. Educ. 2015, 92, 708-713. PDF
Polycarbonate, organocatalytic ROP, polymer synthesis
22. Antimicrobial Hydrogels: A New Weapon in the Arsenal against Multidrug Resistant Infections

Ng, V. W. L.; Chan, J. M. W.; Sardon, H.; Ono, R. J.; García, J. M.; Yang, Y. Y.; Hedrick, J. L.

Adv. Drug Deliv. Rev. 2014, 78, 46-62. PDF
Antimicrobial hydrogels, polymers
21. Role of non-covalent and covalent interactions in cargo loading capacity and stability of polymeric micelles

Ke, X.; Ng, V. W. L.; Ono, R. J.; Chan, J. M. W.; Krishnamurthy, S.; Wang, Y.; Hedrick, J. L.; Yang, Y. Y.

J. Control. Release 2014, 193, 9-26. PDF
Polymeric micelles
20. Overcoming Multidrug Resistance in Microbials Using Nanostructures Self-assembled from Cationic Bent-core Oligomers

Liu, S. Q.; Venkataraman, S.; Ong, Z. Y.; Chan, J. M. W.; Yang, C.; Hedrick, J. L.; Yang, Y. Y.

Small 2014, 10, 4130-4135. PDF
Antimicrobial oligomers
19. Chemically Modifiable N-Heterocycle-functionalized Polycarbonates as a Platform for Diverse Smart Biomimetic Nanomaterials

Chan, J. M. W.*; Ke, X.; Engler, A. C.; Sardon, H.; Yang, Y. Y.; Hedrick, J. L.

Chem. Sci. 2014, 5, 3294-3300. PDF

Among “Most downloaded articles” of July 2014.
Charged polycarbonates, polymer synthesis
18. Highly Tunable Polyurethanes: Organocatalyzed Polyaddition and Subsequent Post-polymerization Modification of Pentafluorophenyl Ester Sidechains

Sardon, H.; Chan, J. M. W.; Ono, R. J.; Mecerreyes, D.; Hedrick, J. L.

Polym. Chem. 2014, 5, 3547-3550. PDF
Polyurethane synthesis, postpolymerization modification
17. Organic Acid-Catalyzed Polyurethane Formation via a Dual-Activated Mechanism: Unexpected Preference of N-activation over O-activation of Isocyanates

Sardon, H.; Engler, A. C.; Chan, J. M. W.; García, J. M.; Coady, D. J.; Pascual, A.; Mecerreyes, D.; Jones, G. O.; Rice, J. E.; Horn, H. W.; Hedrick, J. L.

J. Am. Chem. Soc. 2013, 135, 16235-16241. PDF
Polyurethane synthesis, acid catalyzed polymerization
16. Tetra-n-butylammonium Fluoride as an Efficient Transesterification Catalyst for Functionalizing Cyclic Carbonates and Aliphatic Polycarbonates

Chan, J. M. W.*; Sardon, H.; Engler, A. C.; García, J. M.; Hedrick, J. L.

ACS Macro Lett. 2013, 2, 860-864. PDF

Top 20 most read article of the month.
Polycarbonate synthesis, organocatalytic transesterification
15. Polycarbonate-based Brush Polymers with Detachable Disulfide-linked Side Chains

Engler, A. C.; Chan, J. M. W.; Fukushima, K.; Coady, D. J.; Yang, Y. Y.; Hedrick, J. L.

ACS Macro Lett. 2013, 2, 332-336. PDF
Polycarbonates, brush polymers
14. Homogeneous Isocyanate- and Catalyst-free Synthesis of Polyurethanes in Aqueous Media

Sardon, H.; Engler, A. C.; Chan, J. M. W.; Coady, D. J.; O’Brien, J. M.; Mecerreyes, D.; Yang, Y. Y.; Hedrick, J. L.

Green Chem. 2013, 15, 1121-1126. PDF
Polyurethanes, catalyst-free polymerization
13. Accessing New Materials Through Polymerization and Modification of a Polycarbonate with a Pendant Activated Ester

Engler, A. C.; Chan, J. M. W.; Coady, D. J.; O’Brien, J. M.; Sardon, H.; Nelson, A.; Sanders, D. P.; Yang, Y. Y.; Hedrick, J. L.

Macromolecules 2013, 46, 1283-1290. PDF
Polycarbonate synthesis, postpolymerization modification
12. Studies on the Vanadium-Catalyzed Nonoxidative Depolymerization of Miscanthus giganteus-derived Lignin

Chan, J. M. W.; Bauer, S.; Sorek, H.; Sreekumar, S.; Wang, K.; Toste, F. D.

ACS Catal. 2013, 3, 1369-1377. PDF
Lignin depolymerization, catalysis, energy production
11. Tandem Cycloisomerization/Suzuki Coupling of Arylethynyl MIDA Boronates

Chan, J. M. W.; Amarante, G. W.; Toste, F. D.

Tetrahedron 2011, 67, 4306-4312. PDF

Front cover article. Cited on Sigma Aldrich webpage
Cycloisomerization, gold catalysis, MIDA boronates
10. Synthesis of Stair-stepped Polymers Containing Dibenz[a,h]anthracene Subunits

Chan, J. M. W.; Kooi, S. E.; Swager, T. M.

Macromolecules 2010, 43, 2789-2793. PDF
Conjugated polymers, polymer synthesis, polycyclic aromatic, fluorescent
9. Synthesis of J-Aggregating Dibenz[a,j]anthracene-Based Macrocycles

Chan, J. M. W.; Tischler, J. R.; Kooi, S. E.; Bulovic, V., Swager, T. M.

J. Am. Chem. Soc. 2009, 131, 5659-5666. PDF
J-aggregates, conjugated macrocycle, pi-conjugated, excitons
8. Synthesis of Arylethynylated Cyclohexa-m-phenylenes via Sixfold Suzuki Coupling

Chan, J. M. W.; Swager, T. M.

Tetrahedron Lett. 2008, 49, 4912-4914. PDF
Conjugated macrocycle, wide bandgap, organic electronics
7. Bisphosphonate Inhibitors of ATP-mediated HIV-1 Reverse Transcriptase Catalyzed Excision of Chain-terminating 3′-azido, 3′-deoxythymidine: A QSAR Investigation

Song, Y.; Chan, J. M. W.; Tovian, Z.; Secrest, A.; Nagy, E.; Krysiak, K.; Bergan, K.; Parniak, M. A.; Oldfield, E.

Bioorg. Med. Chem. 2008, 16, 8959-8967. PDF
Bisphosphonate synthesis, HIV
6. Inhibition of Trypanosoma cruzi Hexokinase by Bisphosphonates

Hudock, M. P.; Sanz-Rodriguez, C. E.; Song, Y.; Chan, J. M. W.; Zhang, Y.; Odeh, S.; Kosztowski, T.; Leon-Rossell, A.; Concepcion, J. L.; Yardley, V.; Croft, S. L.; Urbina, J. A.; Oldfield, E.

J. Med. Chem. 2006, 49, 215-223. PDF
Bisphosphonates, anti-protozoan, antiparasitic
5. Bisphosphonate Inhibition of the Exopolyphosphatase Activity of the Trypanosoma brucei Soluble Vacuolar Pyrophosphatase

Kotsikorou, E.; Song, Y.; Chan, J. M. W.; Faelens, S.; Tovian, Z.; Broderick, E.; Bakalara, N.; Docampo, R.; Oldfield, E.

J. Med. Chem. 2005, 48, 6128-6139. PDF
Bisphosphonate, anti-parasitic, drug candidate
4. Pyridinium-1-yl Bisphosphonates are Potent Inhibitors of Farnesyl Diphosphate Synthase and Bone resorption

Sanders, J. M.; Song, Y.; Chan, J. M. W.; Jennings, S.; Zhang, Y.; Kosztowski, T.; Odeh, S.; Flessner, R.; Kotsikorou, E.; Meints, G.; Gomez, A. O.; Gonzalez-Pacanowska, D.; Raker, A. M.; Wang, H.; Morita, C. T.; Oldfield, E.

J. Med. Chem. 2005, 48, 2957-2963. PDF
Charged bisphosphonate, FPP synthase inhibitor
3. Bisphosphonate Inhibitors of Toxoplasma gondi Growth: In Vitro, QSAR and In Vivo Investigations

Ling, Y.; Sahota, G.; Odeh, S.; Chan, J. M. W.; Araujo, F. G.; Moreno, S. N. J.; Silvia, N. J.; Oldfield, E.

J. Med. Chem. 2005, 48, 3130-3140. PDF
Bisphosphonates, toxoplasma gondii
2. Quantitative Structure-Activity Relationships for ɣ,δ T-Cell Activation by Bisphosphonates

Sanders, J. M.; Ghosh, S.; Chan, J. M. W.; Meints, G. A.; Wang, H.; Raker, A. M.; Song, Y.; Colantino, A.; Burzynska, A.; Kafarski, P.; Morita, C. T.; Oldfield, E.

J. Med. Chem. 2004, 47, 375-384. PDF
Bisphosphonates, T-cell activation, immunostimulation
1. Effects of Bisphosphonates on the Growth of Entamoeba histolytica and Plasmodium Species in vitro and in vivo

Ghosh, S.; Chan, J. M. W.; Lea, C. R.; Meints, G. A.; Lewis, J. C.; Tovian, Z. S.; Flessner, R. M.; Loftus, T. C.; Bruchhaus, I.; Kendrick, H.; Croft, S. L.; Kemp, R. G.; Kobayashi, S.; Nozaki, T.; Oldfield, E.

J. Med. Chem. 2004, 47, 175-187. PDF
Bisphosphonates, antiparasitic, antiprotozoan drug

Patents

8. Chan, J. M. W.; Hedrick, J. L.; Ono, R. J.; Teo, J. Y.; Yang, Y. Y.; Zhang, M. S. “Antimicrobial Polymers Formed by Bulk Polyaddition”, U.S. Patent App. 14/749,764, 2015.
7. Chan, J. M. W.; Wojtecki, R. J.; Hedrick, J. L.; Yang, Y. Y.; Lee, A. L. Z. “Biodegradable Organic Radical-Functionalized Polycarbonates for Medical Applications”, U.S. Patent App. 14/609,778, 2015.
6.  Breyta, G.; Chan, J. M. W.; Coady, D. J.; Engler, A. C.; Garcia, J. M.; Han, W.; Hedrick, J. L.; Liu, S.; Nelson, A.; Ono, R. J.; Teo, J. Y.; Yang, Y. Y.; Zhang, M. S. “Condensation Polymerization for Antimicrobial Applications”, U.S. Patent App. 14/705,451, 2015.
5.  Chan, J. M. W.; Coady, D. J.; Engler, A. C.; Garcia, J. M.; Hedrick, J. L.; Ong, Z. Y.; Sardon, H.; Yang, Y. Y. “Catalyst-free methods of forming polyurethanes from pentafluorophenyl carbonates”, U.S. Patent 9,062,160, 2015.
4.  Lin, B. F.; Chan, J. M. W.; Nelson, A.; Engler, A. C.; Hedrick, J. L.; Maune, H. “Irreversibly Degradable Polycarbonate-based Complex Coacervate”, Patent disclosure, 2014.
3.  Chan, J. M. W.; Engler, A. C.; Sardon, H.; Hedrick, J. L.; Yang, Y. Y. “Polycarbonates Bearing Aromatic N-Heterocycles for Drug Delivery”, U.S. Patent App. 14/097488, 2013.
2.  Sanders, J. M.; Song, Y.; Chan, J. M. W.; Oldfield, E.; Zhang, Y. “Bisphosphonate compounds and methods for bone resorption diseases, cancer, bone pain, immune disorders and infectious diseases”, U.S. Patent 8,071,573, 2011.
1.  Parniak, M.; Mellors, J. W.; Oldfield, E.; Tovian, Z.; Chan, J. M. W. “Composition and Methods for Use of Antiviral Drugs in the Treatment of Retroviral Diseases Resistant to Nucleoside Reverse Transcriptase Inhibitors”, U.S. patent application 10/937,683, 2005.

Conferences / Invited Talks

11. Chan, J. M. W. “Designing Sulfonamide-based π-conjugated Systems for Organic Electronics”, 100th Canadian Chemistry Conference and Exhibition, Toronto, ON, Canada, 2017.
10. Chan, J. M. W. “Organic Electronic Materials via Molecular Design and Synthesis”, New Professors Lecture Program, Ottawa, ON, Canada, 2017. Invited.
9. Chan, J. M. W. “Designing Sulfonamide-based π-conjugated Systems for Organic Electronics”, 99th Canadian Chemistry Conference and Exhibition, Halifax, NS, Canada, 2016.
8. Chan, J. M. W. “Introduction to the Synthesis of π-Conjugated Polymers”, National University of Singapore, 2014.
7. Chan, J. M. W.; Sardon, H.; Engler, A. C.; Hedrick, J. L. “Organocatalytic methods and postpolymerization modification strategies for functional aliphatic polycarbonate synthesis”, 247th ACS National Meeting & Exposition, Dallas, TX, 2014.
6. Chan, J. M. W. “Design and Synthesis of Organic Materials: From Conjugated Macrocycles to Functional Polycarbonates”, UC Riverside, CA, 2014.
5. Chan, J. M. W. “Making and Breaking Macromolecules: From Electronic Materials to Biomass”, University talk, ARC, San Jose, CA, 2012.
4. Chan, J. M. W.; Swager, T. M. “Synthesis of Dibenz[a,j]anthracene-based J-aggregates”, MIT Research Symposium in Organic and Bioorganic Chemistry, Cambridge, MA, 2009.
3. Chan, J. M. W.; Swager, T. M. “Synthesis of Functionalized Hexa-m-phenylenes”, 234th ACS National Meeting, Boston, MA, 2007.
2. Chan, J. M. W.; Swager, T. M. “Synthesis of Novel Kekulene-type Torands”, 21st International Liquid Crystal Conference, Keystone, CO, 2006.
1. Chan, J. M. W.; Oldfield, E. “Design and Synthesis of Pharmaceutical Bisphosphonates”, Colgate-Palmolive Symposium, Urbana, IL, 2002.

Contributed Articles

11. Tischler, J. R.; Akselrod, G. M.; Bradley, M. S.; Chan, J.; Young, E. R.; Nocera, D. G.; Swager, T. M.; Bulović, V. “Strong Light-Matter Coupling Using a Robust Non-cyanine Dye J-aggregate Material”, MTL Annual Research Report, 2009. PDF
10. Swager, T. M.; Chan, J. M. W. “Dendron-Modified Multi-Wall Carbon Nanotubes”, Synfacts 2007, 2, 0158.
9. Swager, T. M.; Chan, J. M. W. “Stacked Conjugated Oligothiophenes”, Synfacts 2007, 1, 0039.
8. Swager, T. M.; Chan, J. M. W. “Preparation of Novel Tetrathia[7]helicenes”, Synfacts 2007, 1, 0038.
7. Swager, T. M.; Chan, J. M. W. “Preparation of N-Substituted Diaza[12]annulenes”, Synfacts 2006, 12, 1233.
6. Swager, T. M.; Chan, J. M. W. “Synthesis of Fluorescent Dialkynylboradiazaindacenes”, Synfacts 2006, 12, 1226.
5. Swager, T. M.; Chan, J. M. W. “Synthesis of Stackable Pseudo-Triphenylenes”, Synfacts 2006, 11, 1123.
4. Swager, T. M.; Chan, J. M. W. “Preparation of Thiaphlorins and Related Dyads”, Synfacts 2006, 11, 1117.
3. Swager, T. M.; Chan, J. M. W. “Synthesis of Polyvinylenephosphines”, Synfacts 2006, 10, 1016.
2. Swager, T. M.; Chan, J. M. W. “Synthesis of Thiadiazole-Containing Polycyclic Aromatic Systems”, Synfacts 2006, 10, 1008.
1. Swager, T. M.; Chan, J. M. W. “Synthesis of a Poly(sulfamide) from Sulfur Dioxide”, Synfacts 2006, 9, 0902.